An efficient nickel/silver co-catalyzed remote C–H amination of 8-aminoquinolines with azodicarboxylates at room temperature. Issue 65 (5th November 2018)

• Record Type: Journal Article
• Authors: Zhao, Ruinan; Yang, Yaocheng; Wang, Xia; Ren, Peng; Zhang, Qian; Li, Dong
• Is Part Of: RSC advances. Volume 8:Issue 65(2018)
• Page Start: 37064
• Page End: 37068
• Publication Date: 2018-11-05
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra07647b
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : C–H amination at the C5 position of 8-aminoquinolines with azodicarboxylates proceeded efficiently using a nickel/silver co-catalyst at room temperature without any additional ligand, base or oxidant. Abstract : A highly efficient nickel/silver co-catalyzed C–H amination at the C5 position of 8-aminoquinolines with azodicarboxylates at room temperature is reported. The reaction undergoes a self-redox process without the necessity of external oxidant. It proceeded under simple and mild conditions without any additional ligand, base or oxidant and provided the desired products in good to excellent yields. This method also possessed the merits of good functional group compatibility and air and moisture tolerance. It provides an efficient strategy for the synthesis of useful quinoline derivatives.