Iron-catalyzed synthesis of cyclopropanes by in situ generation and decomposition of electronically diversified diazo compounds. Issue 94 (9th November 2018)

• Record Type: Journal Article
• Authors: Allouche, Emmanuelle M. D.; Al-Saleh, Afnan; Charette, André B.
• Is Part Of: Chemical communications. Volume 54:Issue 94(2018)
• Page Start: 13256
• Page End: 13259
• Publication Date: 2018-11-09
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc07060a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The modular synthesis of a variety of trans 1, 2-disubstituted cyclopropanes in a one-pot iron-catalyzed cyclopropanation is described. N -nosylhydrazones are used as diazo precursors, allowing the in situ generation of electron-rich diazo compounds and their direct participation in the reaction. Abstract : The modular synthesis of a variety of trans 1, 2-disubstituted cyclopropanes in a safe and user-friendly one-pot iron-catalyzed cyclopropanation reaction is described. Easily synthesized N -nosylhydrazones are used as diazo precursors, allowing the in situ generation of electron-rich diazo compounds under mild reaction conditions and their direct participation in the cyclopropanation reaction.