An integrated immobilization strategy manipulates dual active centers to boost enantioselective tandem reactions. Issue 94 (9th November 2018)

• Record Type: Journal Article
• Authors: Shu, Xiaomin; Jin, Ronghua; Zhao, Zhongrui; Cheng, Tanyu; Liu, Guohua
• Is Part Of: Chemical communications. Volume 54:Issue 94(2018)
• Page Start: 13244
• Page End: 13247
• Publication Date: 2018-11-09
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc07841f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A bifunctional catalyst assembled by dual species manipulation presents high efficiency in Suzuki coupling-asymmetric transfer hydrogenation tandem reactions. Abstract : Manipulation of dual active centers via an integrated immobilization strategy can overcome the restriction of homogeneous catalysis in a sequential organic transformation. Herein, by utilizing hollow-shell-structured silica, hydrogen-bonding immobilization via a ship-in-a-bottle synthesis locks a Pd(carbene) center in a nanocage and covalent-bonding immobilization tethers chiral Ru(diamine) centers within the nanochannels, constructing a hetero-bifunctional catalyst. The benefit of this dual center manipulation enables a challenging Suzuki coupling-asymmetric transfer hydrogenation tandem reaction, and the advantage of this process provides various chiral biarylols with enhanced reactivity and enantioselectivity.