Adhesion-based sorting of blood cells: an adhesive dynamics simulation study. Issue 44 (5th November 2018)

• Record Type: Journal Article
• Authors: Dasanna, Anil K.; Schwarz, Ulrich S.
• Is Part Of: Soft matter. Volume 14:Issue 44(2018)
• Page Start: 9061
• Page End: 9070
• Publication Date: 2018-11-05
• Subjects: Soft condensed matter -- Periodicals; 530.413
• DOI: 10.1039/c8sm01524d
• Languages: English
• ISSNs: 1744-683X

Abstract

Abstract : Both leukocytes and malaria-infected red blood cells can be sorted by adhesive stripe assays with optimized inclination angles. Abstract : Blood cells can be sorted in microfluidic devices not only based on their sizes and deformability, but also based on their adhesive properties. In particular, white blood cells have been shown to be sorted out by using adhesive micropatterns made from stripes that are tilted in regard to the direction of shear flow. Here we use adhesive dynamics simulations for round cells to quantitatively investigate this effect and to predict the optimal tilt angle. We then apply our method to predict optimal sorting conditions for malaria-infected red blood cells, which like white blood cells also adhere to and roll on adhesive substrates.