Corygaline A, a hexahydrobenzophenanthridine alkaloid with an unusual carbon skeleton from Corydalis bungeana Turcz. Issue 45 (9th November 2018)

• Record Type: Journal Article
• Authors: Gao, Chang; Gu, Xiaoting; Wang, Xin; Cao, Huikun; Lin, Bin; Liu, Youping; Di, Xin
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 45(2018)
• Page Start: 8710
• Page End: 8714
• Publication Date: 2018-11-09
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob02194e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A novel hexahydrobenzophenanthridine alkaloid, corygaline A (1 ), was isolated from Corydalis bungeana Turcz. Abstract : A novel hexahydrobenzophenanthridine alkaloid, corygaline A (1 ), was isolated from Corydalis bungeana Turcz. Its structure and absolute configuration were elucidated by spectroscopic data analysis and electronic circular dichroism (ECD) calculations. Corygaline A (1 ) is the first example of an alkaloid which features a 6/6/6/6/6-fused pentacyclic skeleton in nature. It exhibited significant NO production inhibitory activity in LPS-activated RAW264.7 macrophages with an IC50 value of 2.9 μM. A plausible biosynthetic pathway for1 is also discussed.