Arsenic trioxide preferentially binds to the ring finger protein PML: understanding target selection of the drug. Issue 11 (27th September 2018)

• Record Type: Journal Article
• Authors: Kaiming, Cao; Sheng, Yaping; Zheng, Shihui; Yuan, Siming; Huang, Guangming; Liu, Yangzhong
• Is Part Of: Metallomics. Volume 10:Issue 11(2018)
• Page Start: 1564
• Page End: 1569
• Publication Date: 2018-09-27
• Subjects: Metals -- Physiological effect -- Periodicals; 572.51
• DOI: 10.1039/c8mt00202a
• Languages: English
• ISSNs: 1756-5901

Abstract

Abstract : Arsenite preferentially binds to the ring-finger protein of PML and arsenic can transfer from As-bound zinc-fingers to PML. Abstract : Arsenic trioxide (ATO) is used in the clinic for the treatment of acute promyelocytic leukemia by targeting the protein PML. However, many zinc-finger proteins could also be reactive to arsenic in cells. Here we found that ATO preferentially binds to the ring-finger domain of PML in a protein mixture with zinc-finger domains. These results provide the molecular basis of the target selection of ATO in cells.