A facile tandem decyanation/cyanation reaction of α-iminonitriles toward cyano-substituted amides. Issue 44 (31st October 2018)

• Record Type: Journal Article
• Authors: Chen, Zhengwang; Liang, Pei; Liu, Botao; Luo, Haiqing; Zheng, Jing; Wen, Xiaowei; Liu, Tanggao; Ye, Min
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 44(2018)
• Page Start: 8481
• Page End: 8485
• Publication Date: 2018-10-31
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob02186d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient method for cyano-substituted amides via a tandem decyanation/cyanation reaction of α-iminonitriles. Abstract : A new tandem decyanation/cyanation reaction of α-iminonitriles has been developed. A variety of cyano-substituted aryl amides and heteroaryl amides are synthesized in good yields. Both electron-rich and electron-deficient groups are compatible with the standard conditions. This reaction features a nonmetallic cyano source, tandem decyanation and cyanation reaction, waste utilization of the HCN from the hydrolysis of α-iminonitriles, formation of two important functional groups in one-step operation, etc .