End-tidal carbon dioxide during pediatric in-hospital cardiopulmonary resuscitation. (December 2018)

• Record Type: Journal Article
• Authors: Berg, Robert A.; Reeder, Ron W.; Meert, Kathleen L.; Yates, Andrew R.; Berger, John T.; Newth, Christopher J.; Carcillo, Joseph A.; McQuillen, Patrick S.; Harrison, Rick E.; Moler, Frank W.; Pollack, Murray M.; Carpenter, Todd C.; Notterman, Daniel A.; Holubkov, Richard; Dean, J. Michael; Nadkarni, Vinay M.; Sutton, Robert M.
• Is Part Of: Resuscitation. Volume 133(2018)
• Page Start: 173
• Page End: 179
• Publication Date: 2018-12
• Subjects: CPR cardiopulmonary resuscitation -- CPCCRN Collaborative Pediatric Critical Care Research Network -- PICqCPR study Pediatric Intensive Care Quality of CPR study -- DBP diastolic blood pressure -- ROSC return of spontaneous circulation -- ICU intensive care unit -- PCPC Pediatric cerebral performance category -- DCC Data Coordinating Center; Cardiopulmonary resuscitation (CPR) -- Cardiac arrest -- End-tidal carbon dioxide (ETCO2) -- Pediatric -- In-hospital -- Survival; Resuscitation -- Periodicals; Resuscitation -- Periodicals; Réanimation -- Périodiques; Electronic journals; 616.025
• DOI: 10.1016/j.resuscitation.2018.08.013
• Languages: English
• ISSNs: 0300-9572

Abstract

Abstract: Background: Based on laboratory cardiopulmonary resuscitation (CPR) investigations and limited adult data, the American Heart Association Consensus Statement on CPR Quality recommends titrating CPR performance to achieve end-tidal carbon dioxide (ETCO2) >20 mmHg. Aims: We prospectively evaluated whether ETCO2 > 20 mmHg during CPR was associated with survival to hospital discharge. Methods: Children ≥37 weeks gestation in Collaborative Pediatric Critical Care Research Network intensive care units with chest compressions for ≥1 min and ETCO2 monitoring prior to and during CPR between July 1, 2013 and June 31, 2016 were included. ETCO2 and Utstein-style cardiac arrest data were collected. Multivariable Poisson regression models with robust error estimates were used to estimate relative risk of outcomes. Results: Blinded investigators analyzed ETCO2 waveforms from 43 children. During CPR, the median ETCO2 was 23 mmHg [quartiles, 16 and 28 mmHg], median ventilation rate was 29 breaths/min [quartiles, 24 and 35 breaths/min], and median duration of CPR was 5 min [quartiles, 2 and 16 min]. Return of spontaneous circulation occurred after 71% of CPR events and 37% of patients survived to hospital discharge. For children with mean ETCO2 during CPR > 20 mmHg, the adjusted relative risk for survival was 0.92 (0.41, 2.08), p = 0.84. The median mean ETCO2 among children who survived to hospital discharge was 20 mmHg [quartiles; 15, 28 mmHg] versus 23 mmHg [16, 28 mmHg] among non-survivors. Conclusion: Mean ETCO2 > 20 mmHg during pediatric in-hospital CPR was not associated with survival to hospital discharge, and ETCO2 was not different in survivors versus non-survivors.