Planar cell polarity in organ formation. (December 2018)

• Record Type: Journal Article
• Authors: Henderson, Deborah J; Long, David A; Dean, Charlotte H
• Is Part Of: Current opinion in cell biology. Volume 55(2018)
• Page Start: 96
• Page End: 103
• Publication Date: 2018-12
• Subjects: Cells -- Periodicals; Cytology -- Periodicals; Cell Biology -- Periodicals; Biology -- Periodicals; Cells -- Periodicals; Review Literature -- Periodicals; Cell Biology; Biology; Cells; Review Literature; Cellules -- Périodiques; Cytologie -- Périodiques; Electronic journals; 571.6
• DOI: 10.1016/j.ceb.2018.06.011
• Languages: English
• ISSNs: 0955-0674

Abstract

Abstract : The planar cell polarity (PCP) pathway controls a variety of morphological events across many species. During embryonic development, the PCP pathway regulates coordinated behaviour of groups of cells to direct morphogenetic processes such as convergent extension and collective cell migration. In this review we discuss the increasingly prominent role of the PCP pathway in organogenesis, focusing on the lungs, kidneys and heart. We also highlight emerging evidence that PCP gene mutations are associated with adult diseases.