Liver transplant pathology: a timeline based approach and review. Issue 12 (December 2018)

• Record Type: Journal Article
• Authors: Byrnes, Kathleen; Oshima, Kiyoko
• Is Part Of: Diagnostic histopathology. Volume 24:Issue 12(2018)
• Page Start: 508
• Page End: 513
• Publication Date: 2018-12
• Subjects: allografts -- donor -- graft rejection -- liver pathology -- liver transplantation; Histology, Pathological -- Periodicals; Cytodiagnosis -- Periodicals; Diagnosis, Laboratory -- Periodicals; Pathology -- Periodicals; Histopathologie -- Périodiques; Pathologie -- Périodiques; Cytodiagnostics -- Périodiques; Diagnostics biologiques -- Périodiques; Histologie -- Technique -- Périodiques; Electronic journals; 616.07582
• DOI: 10.1016/j.mpdhp.2018.09.002
• Languages: English
• ISSNs: 1756-2317

Abstract

Abstract: Liver transplantation is becoming more widely used for the treatment of numerous diseases. Liver pathology has an important role in both donor selection and guidance for treatment decisions to preserve allografts. Pathologists are increasingly requested to perform frozen section analysis of donor liver because suboptimal allografts need to be utilized because of the shortage of available donor livers. Post-transplant liver biopsies can seem overwhelming due to the wide differential diagnosis compared to that for non-allograft liver biopsies. When evaluating allograft liver biopsies, attention to the morphologic pattern and correlation with clinical findings is essential. This review provides a brief overview of the differential diagnoses encountered in allograft biopsies and a guide to diagnosis using histologic findings and the timeline after transplantation.