Maternal diet of polyunsaturated fatty acid influence the physical and neurobehaviour of rat offspring. Issue 71 (December 2018)

• Record Type: Journal Article
• Authors: Yang, Rui; Liu, Shao; Zheng, Yi; Zhang, Mengqi; Dang, Ruili; Tang, Mimi
• Is Part Of: International journal of developmental neuroscience. Issue 71(2018:Dec.)
• Page Start: 156
• Page End: 162
• Publication Date: 2018-12
• Subjects: AA arachidonic acid -- ALA α-linoleic acid -- CNS central nervous system -- DHA docosahexanoic acid -- EPA eicosapentaenoic acid -- LA linoleic acid -- PND postnatal day -- PUFAs polyunsaturated fatty acids -- RGCs retina ganglion cells -- SIDS sudden infant death syndrome; Maternal diet -- Polyunsaturated fatty acids -- Physical development -- Neurobehavioral -- Development; Developmental neurobiology -- Periodicals; Neurology -- Periodicals; Neurologie du développement -- Périodiques; Developmental neurobiology; Periodicals; 612.8
• DOI: 10.1016/j.ijdevneu.2018.09.005
• Languages: English
• ISSNs: 0736-5748

Abstract

Highlights: The new insight into the link between the n-3 PUFAs and the physical and neurobehaviour of the rat offspring. The effects of maternal n-3 polyunsaturated fatty acids (PUFAs) dietary on physical maturation and neurobiological development of the rat offspring. N-3 PUFAs supplementary during the maternal could prevent neonatal obesity, accelerate the maturation of cerebellar and vestibular system function in offspring. Abstract: Background: Polyunsaturated fatty acids (PUFAs) are normal components of growth and development and its derivatives especially n-3 PUFAs have an influence on the development and maturation of nervous system. The purpose of our present study was to investigate the effect of maternal n-3 PUFAs dietary on physical maturation and the neurobiological development of the rat offspring. Methods: According to the content of n-3 PUFAs in their diets, female dams were randomly divided into three treatment groups (n = 6–7): deficiency, control and supplementation. The physical parameters and neurobehavioral tests were measured in the rats' offspring. Results: There were no significant differences in litter size and sex ratio between three groups. However, the ratio of brain/body weight was higher in the deficiency pups than the control. As to the body weight, the deficiency pups were heavier than the control pups on postnatal day (PND) 1, PND7, PND14, and PND21, while supplementation pups were lower than the control pups on PND1. There are no significant differences in the physical parameters of incisor eruption and fur appearance between three groups. However, deficiency pups had earlier eye opening than the control pups. Unfortunately, there were no significant differences in surface righting reflex, cliff avoidance, forelimb grip and air righting reflex. Whereas, supplementation pups required less time to complete negative geotaxis than the control pups on PND17. Conclusion: This study suggests that the consumption of adequate n-3 PUFAs is benefit for the optimal growth and development of rat offspring. The n-3 PUFAs supplementation is beneficial to population that did not have sufficient provision of n-3 PUFAs in the diet during gestation and lactation.