Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document. Section I: Pathophysiology of Atopic Dermatitis and Implications for Systemic Therapy. Issue 1 (November 2018)

• Record Type: Journal Article
• Authors: Kirchhof, Mark G.; Landells, Ian; Lynde, Chuck W.; Gooderham, Melinda J.; Hong, Chih-ho
• Is Part Of: Journal of cutaneous medicine and surgery. Volume 22:Issue 1(2018)Supplement
• Page Start: 6S
• Page End: 9S
• Publication Date: 2018-11
• Subjects: atopic dermatitis -- pathophysiology -- systemic therapy; Dermatology -- Periodicals; Skin -- Diseases -- Treatment -- Periodicals; Skin -- Surgery -- Periodicals; Dermatology -- Canada -- Periodicals; Skin -- Diseases -- Treatment -- Canada -- Periodicals; Skin -- Surgery -- Canada -- Periodicals; 616.5005
• DOI: 10.1177/1203475418803626
• Languages: English
• ISSNs: 1203-4754

Abstract

Atopic dermatitis (AD) is a chronic, relapsing, and remitting inflammatory skin disease whose onset typically occurs early in life. AD pathophysiology includes genetic, immune, and environmental factors contributing to chronic inflammation. A rapidly evolving understanding of the pathogenesis of AD has led to the development of several treatment options for AD in adults, including topicals, phototherapy, and systemic therapies. Here, we provide a concise summary of AD pathophysiology with a focus on implications for systemic therapy.