A single institutional experience of combined carbon-ion radiotherapy and chemotherapy for unresectable locally advanced pancreatic cancer. Issue 2 (November 2018)

• Record Type: Journal Article
• Authors: Shinoto, Makoto; Terashima, Kotaro; Suefuji, Hiroaki; Matsunobu, Akira; Toyama, Shingo; Fukunishi, Kaori; Shioyama, Yoshiyuki
• Is Part Of: Radiotherapy and oncology. Volume 129:Issue 2(2018)
• Page Start: 333
• Page End: 339
• Publication Date: 2018-11
• Subjects: Carbon-ion radiotherapy -- Locally advanced -- Pancreatic cancer; Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2018.08.026
• Languages: English
• ISSNs: 0167-8140

Abstract

Highlights: We analyzed 64 LAPC patients treated with C-ion RT at single institution. The median survival time and 2-year OS were 25.1 months and 53%. Only four patients experienced acute grade 3 toxicities. C-ion RT for LAPC showed relatively favorable outcome and limited toxicity. Abstract: Purpose: The aim of this study was to evaluate the efficacy and safety of carbon-ion radiotherapy (C-ion RT) for unresectable locally advanced pancreatic cancer (LAPC). Methods and materials: Patients with LAPC treated with definitive C-ion RT between April 2014 and July 2017 were analyzed retrospectively. The prescribed dose was 55.2 Gy (relative biological effectiveness [RBE] weighted absorbed dose) in 12 fractions. Overall survival (OS), local control (LC), progression free survival (PFS), and toxicity were evaluated. Results: Sixty-four patients were enrolled. All patients completed planned course of C-ion RT. The median follow-up time for survivors from the initiation of C-ion RT was 24.4 months (range, 5.1–46.1 months). Median survival time was 25.1 months. Two-year OS, LC, and PFS were 53% (95% confidence interval [CI], 39%–66%), 82% (95% CI, 66%–91%), and 23% (95% CI, 14%–36%), respectively. Four patients experienced acute grade 3 toxicities including 3 gastrointestinal (GI) toxicities. There was no grade 3 or more late toxicity. Conclusions: The clinical results of C-ion RT for LAPC at our institution were comparable to those of a recent multi-institutional analysis.