Influence of Apolipoprotein E on the Lipid Profile and Postprandial Triglyceride Levels in Brazilian Postmenopausal Women With Artery Disease. Issue 11 (20th September 2017)

• Record Type: Journal Article
• Authors: Tácito, Lúcia Helena Bonalume; Yamada, Lilian Nakachima; de Souza Pinhel, Marcela Augusta; Yugar-Toledo, Juan Carlos; Souza, Dorotéia Rossi Silva
• Is Part Of: Clinical Medicine Insights. Issue 11(2017)
• Publication Date: 2017-09-20
• Subjects: Coronary artery disease -- postmenopause -- apolipoprotein E -- cholesterol -- postprandial triglycerides; Cardiovascular system -- Diseases -- Periodicals; Cardiology -- Periodicals; Cardiovascular Diseases; Cardiology; Cardiovascular system -- Diseases; Electronic journals; Periodicals; Fulltext; Internet Resources; Periodicals; Periodicals; 616.12
• DOI: 10.1177/1179546817731110
• Languages: English
• ISSNs: 1179-5468

Abstract

This study confirms the association of risk factors for coronary artery disease (CAD) and the apoE polymorphisms, specifically related to the APOE*4 allele, with coronary disease in postmenopausal women. Significantly altered values of the lipid profile were found in patients when compared with controls, independent of the presence of the APOE*4 allele. However, the controls showed higher high-density lipoprotein cholesterol (HDL-C) levels and reduced triglyceride (TG) levels, differing significantly from patients. In this case, the study of subgroups, considering the APOE*3/3 and APOE*3/4 genotypes, suggests that the APOE*4 allele is not implicated in the variations of the lipid profile of patients and determined an increase in the production levels of HDL-C and a reduction in TG highly benefiting the control group compared with APOE*3/3 genotype. The metabolic kinetics of TG, although with the same pattern between groups, and the presence of the APOE*4 allele are suggested to be associated with accelerated clearance compared with APOE*3 allele in non-CAD group.