Inflammation and Epithelial-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma: Fighting Against Multiple Opponents. (12th May 2017)

• Record Type: Journal Article
• Authors: Khalafalla, Farid G; Khan, Mohammad W
• Is Part Of: Cancer growth and metastasis. Volume 10(2017)
• Publication Date: 2017-05-12
• Subjects: Inflammation -- PDAC -- EMT -- chemoresistance; Cancer -- Periodicals; Metastasis -- Periodicals; Neoplasm metastasis; Medical Oncology; Cancer; Metastasis; Electronic journals; Periodicals; Periodicals; 616.99400285
• DOI: 10.1177/1179064417709287
• Languages: English
• ISSNs: 1179-0644

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer and one of the most lethal human cancers. Inflammation is a critical component in PDAC initiation and progression. Inflammation also contributes to the aggressiveness of PDAC indirectly via induction of epithelial-mesenchymal transition (EMT), altogether leading to enhanced resistance to chemotherapy and poor survival rates. This review gives an overview of the key pro-inflammatory signaling pathways involved in PDAC pathogenesis and discusses the role of inflammation in induction of EMT and development of chemoresistance in patients with PDAC.