Regulatory RNAs discovered in unexpected places. (1st October 2015)

• Record Type: Journal Article
• Authors: Pek, Jun Wei; Okamura, Katsutomo
• Is Part Of: Wiley interdisciplinary reviews. Volume 6:Number 6(2015:Nov./Dec.)
• Page Start: 671
• Page End: 686
• Publication Date: 2015-10-01
• Subjects: RNA -- Periodicals; 572.8805
• DOI: 10.1002/wrna.1309
• Languages: English
• ISSNs: 1757-7004

Abstract

Abstract : Recent studies have discovered both small and long noncoding RNAs (ncRNAs) encoded in unexpected places. These ncRNA genes were surprises at the time of their discovery, but many quickly became well‐accepted families of functional regulatory RNA species. Even after years of extensive gene annotation studies using high‐throughput sequencing technologies, new types of ncRNA genes continue to be discovered in unexpected places. We highlight ncRNAs that have atypical structures and that are encoded in what are generally considered 'junk' sequences, such as spacers and introns. We also discuss current bottlenecks in the approaches for identifying novel ncRNAs and the possibility that many remain to be discovered. WIREs RNA 2015, 6:671–686. doi: 10.1002/wrna.1309 This article is categorized under: RNA Evolution and Genomics > Computational Analyses of RNA RNA Turnover and Surveillance > Regulation of RNA Stability Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs