Association of Vitiligo and Response in Patients with Metastatic Malignant Melanoma on Temozolomide. Issue 2 (March 2015)

• Record Type: Journal Article
• Authors: Tatli, Ali Murat; Besen, Ali Ayberk; Kalender, Mehmet Emin; Uysal, Mukremin; Asian, Deniz; Goksu, Sema Sezgin; Gunduz, Seyda Gulenay; Coskun, Hasan Senol
• Is Part Of: Tumori. Volume 101:Issue 2(2015)
• Page Start: e67
• Page End: e69
• Publication Date: 2015-03
• Subjects: Malignant melanoma -- Temozolomide -- Vitiligo-like lesions; Cancer -- Periodicals; 616.994
• DOI: 10.5301/tj.5000253
• Languages: English
• ISSNs: 0300-8916

Abstract

Vitiligo-like lesions, although rare, are believed to be a prognostic factor in malignant melanoma. While a predictive role for such lesions was shown with immunomodulatory therapies, this relation was not demonstrated with temozolomide. We present 3 patients with metastatic malignant melanoma who developed vitiligo-like skin lesions accompanying good response to treatment and prolonged survival. Onset of vitiligo-like lesions with temozolomide in metastatic malignant melanoma may predict long-term response for this treatment.