Radiotherapy for Early-Stage Prostate Cancer in Men under 70 Years of Age. Issue 2 (March 2016)

• Record Type: Journal Article
• Authors: Bellavita, Rita; Scricciolo, Melissa; Bini, Vittorio; Arcidiacono, Fabio; Montesi, Giampaolo; Lancellotta, Valentina; Zucchetti, Claudio; Lupattelli, Marco; Palumbo, Isabella; Aristei, Cynthia
• Is Part Of: Tumori. Volume 102:Issue 2(2016)
• Page Start: 209
• Page End: 216
• Publication Date: 2016-03
• Subjects: Dose -- Prostate cancer -- Radical radiotherapy; Cancer -- Periodicals; 616.994
• DOI: 10.5301/tj.5000433
• Languages: English
• ISSNs: 0300-8916

Abstract

Aims: To demonstrate that radiotherapy (RT) is a valid alternative to surgery in men ≤70 years old with localized prostate cancer. Methods: From 1988 to 2009, 214 patients with T1-2 N0 M0 prostate cancer were treated with RT. The effects of patient- and treatment-related risk factors on toxicity were investigated. Results: Median follow-up was 105 months (range 14.2-180). The 5-, 10-, and 15-year biochemical relapse-free survival for all 214 patients was 80%, 61.9%, and 57.5%, respectively. In bivariate analysis, age (≤65 vs 65-70 years) was not a significant factor for biochemical relapse, while radiation dose was (p = 0.05) in multivariate analysis. Cancer-specific survival rates at 5, 10, and 15 years were 98.4%, 93.2%, and 69.7%, respectively. Median overall survival (OS) was 167 months (95% confidence interval 147.3-186.7). The OS rates at 5, 10, and 15 years were 91.8%, 75.8%, and 42.5%, respectively. Acute genitourinary (GU) and gastrointestinal (GI) toxicities occurred in 105 (49%) and 98 patients (45.8%), respectively, with only 2 cases of grade III GI toxicity. Late GU and GI toxicities occurred in 17 (7.9%) and 20 (9.3%) patients, respectively, with 1 grade III GI toxicity and 2 grade III GU toxicities. Risk factors for late toxicity were age and RT dose and technique, which were unrelated to acute toxicity. Conclusions: Age ≤70 years does not consistently confer a negative prognosis for localized prostate cancer. Radiotherapy appears to be a viable alternative to surgery, offering excellent long-term cancer control.