Cell cycle RNA regulons coordinating early lymphocyte development. (23rd February 2017)

• Record Type: Journal Article
• Authors: Galloway, Alison; Turner, Martin
• Is Part Of: Wiley interdisciplinary reviews. Volume 8:Number 5(2017:Sep./Oct.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-02-23
• Subjects: RNA -- Periodicals; 572.8805
• DOI: 10.1002/wrna.1419
• Languages: English
• ISSNs: 1757-7004

Abstract

Abstract : Lymphocytes undergo dynamic changes in gene expression as they develop from progenitor cells lacking antigen receptors, to mature cells that are prepared to mount immune responses. While transcription factors have established roles in lymphocyte development, they act in concert with post‐transcriptional and post‐translational regulators to determine the proteome. Furthermore, the post‐transcriptional regulation of RNA regulons consisting of mRNAs whose protein products act cooperatively allows RNA binding proteins to exert their effects at multiple points in a pathway. Here, we review recent evidence demonstrating the importance of RNA binding proteins that control the cell cycle in lymphocyte development and discuss the implications for tumorigenesis. WIREs RNA 2017, 8:e1419. doi: 10.1002/wrna.1419 This article is categorized under: RNA in Disease and Development > RNA in Disease RNA in Disease and Development > RNA in Development Abstract : RNA binding proteins influence the expression of cell cycle regulators, which then in turn affects the balance of cell cycle progression and V(D)J recombination in developing lymphocytes. In this review, we discuss how RNA binding protein (RBP) regulates the cell cycle and other pathways in developing lymphocytes.