Base‐Promoted Substitution Reaction: A Simple, Economical, and Efficient Method for Obtaining 3‐Sulfenylated Benzo[b]furan Derivatives. Issue 1 (2nd January 2018) - Wang, Cong
Abstract: A practical and concise protocol for the efficient preparation of 3‐sulfenylated benzo[ b ]furan derivatives via an addition−elimination/vinylic‐nucleophilic substitution reaction is been described. Various substituted 3‐sulfenylated benzo[ b ]furan derivatives were synthesized in good‐to‐excellent yields under basic conditions. Remarkably, this procedure offers several advantages including good yields, mild reaction conditions, simple operation, no requirement of extra metals, and gram‐scale synthesis. Abstract : A concise, economical, and efficient protocol for the synthesis of functionalized 3‐sulfenylated benzo[ b ]furan by the substitution reaction of chlorobenzofuran‐2‐carbonyl compounds with aryl thiols is presented. Diverse 3‐sulfenylated benzo[ b ]furan derivatives could be synthesized with good‐to‐high yield under mild condition.