(NH4)2S2O8‐Mediated Direct Oxysulfonyloxylation of Alkynes with Sulfonic Acids to Access α‐Sulfonyloxyketones. Issue 1 (2nd January 2018)

• Record Type: Journal Article
• Authors: Zhang, Yang; Tan, Hua; Yue, Chaochao; Liu, Weibing
• Is Part Of: ChemistrySelect. Volume 3:Issue 1(2018)
• Page Start: 15
• Page End: 17
• Publication Date: 2018-01-02
• Subjects: alkynes -- oxysulfonyoxylation -- radical tandem addition -- sulfonic acids -- α-sulfonyloxyketones -- (NH4)2S2O8; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201702566
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A novel method for the preparation of α‐sulfonyloxyketones via a (NH4 )2 S2 O8 ‐mediated direct oxysulfonyloxylation of alkynes with sulfonic acids is described. This simple yet powerful method allows access to a variety of α‐sulfonyloxyketones with a broad substrate scope. Furthermore, under the stipulated conditions, this methodology demonstrates excellent regioselectivity for some 1, 2‐disubstituted internal alkyne substrates, affording the corresponding α‐sulfonyloxyketones in good yields. Abstract : This protocol is a novel method for preparation of α‐sulfonyloxyketones via a (NH4 )2 S2 O8 ‐mediated direct oxysulfonyloxylation of alkynes with sulfonic acids. This simple yet powerful method for the synthesis of a variety of α‐sulfonyloxyketones has a broad substrate scope. Furthermore, under the stipulated conditions, this methodology demonstrates excellent regioselectivity for some 1, 2‐disubstituted internal alkyne substrates.