Cover Feature: Activatable Near‐Infrared Probe for Fluorescence Imaging of γ‐Glutamyl Transpeptidase in Tumor Cells and In Vivo (Chem. Eur. J. 59/2017). Issue 59 (22nd August 2017)

• Record Type: Journal Article
• Authors: Luo, Zhiliang; Feng, Liandong; An, Ruibing; Duan, Guanfu; Yan, Runqi; Shi, Hua; He, Jian; Zhou, Zhengyang; Ji, Changge; Chen, Hong‐Yuan; Ye, Deju
• Is Part Of: Chemistry. Volume 23:Issue 59(2017)
• Page Start: 14667
• Page End: 14667
• Publication Date: 2017-08-22
• Subjects: activatable probe -- fluorescence probe -- near-infrared -- tumor imaging -- γ-glutamyl transpeptidase; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201703472
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : An activatable near‐infrared probe was developed by linking of a γ‐glutamyl transpeptidase (GGT)‐recognitive substrate, and a near infrared (NIR) fluorophore with a self‐immolative linker. The probe was stable and could generate significant turn‐on fluorescence in response to GGT. The probe was used for the real‐time imaging of GGT activity and screening of GGT inhibitors both in live tumor cells and mice, allowing for the study and diagnosis of GGT‐related diseases. More information can be found in the Full Paper by D. Ye et al. onpage 14778 .