Cover Feature: Designed Synthesis of Au/Fe3O4@C Janus Nanoparticles for Dual‐Modal Imaging and Actively Targeted Chemo‐Photothermal Synergistic Therapy of Cancer Cells (Chem. Eur. J. 68/2017). Issue 68 (10th October 2017)

• Record Type: Journal Article
• Authors: Zhang, Qi; Zhang, Lingyu; Li, Shengnan; Chen, Xiangjun; Zhang, Manjie; Wang, Tingting; Li, Lu; Wang, Chungang
• Is Part Of: Chemistry. Volume 23:Issue 68(2017)
• Page Start: 17153
• Page End: 17153
• Publication Date: 2017-10-10
• Subjects: carbon -- chemo-photothermal therapy -- gold -- Janus nanoparticles -- magnetite; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201704227
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : A newly developed approach is presented for the fabrication of new generation of Janus nanoparticles (JNPs)—Au/Fe3 O4 @C. These JNPs were functionalized with amino‐poly(ethylene glycol)thiol (NH2 ‐PEG‐SH) and folic acid (FA) on the exposed Au domains, whereas the mesoporous Fe3 O4 @C side served as the drug delivery vehicle of doxorubicin (DOX). The resultant FA‐PEG‐Au/Fe3 O4 @C JNPs were employed as a new theranostic agent for CT and MR imaging‐guided actively targeted chemo‐photothermal synergistic therapy of cancer cells. More information can be found in the Full Paper by L. Li, C. Wang et al. onpage 17242 .