Pre-therapy Neural State of Bilateral Motor and Premotor Cortices Predicts Therapy Gain After Subcortical Stroke: A Pilot Study. (January 2018)

• Record Type: Journal Article
• Authors: Cirstea, Carmen M.; Lee, Phil; Craciunas, Sorin C.; Choi, In-Young; Burris, Joseph E.; Nudo, Randolph J.
• Is Part Of: American journal of physical medicine & rehabilitation. Volume 97:Number 1(2018)
• Publication Date: 2018-01
• Subjects: Glutamatergic and Neuronal State -- Motor and Premotor Cortices -- Chronic Stroke -- Therapy Gain; Rehabilitation -- Periodicals; Medicine, Physical -- Periodicals; 617.062
• DOI: 10.1097/PHM.0000000000000791
• Languages: English
• ISSNs: 0894-9115

Abstract

Abstract : Objective: The aim of the study was to examine whether neural state of spared motor and premotor cortices captured before a therapy predicts therapy-related motor gains in chronic subcortical stroke. Design: Ten survivors, presenting chronic moderate upper limb impairment, underwent proton magnetic resonance spectroscopy, magnetic resonance imaging, clinical, and kinematics assessments before a 4-wk impairment-oriented training. Clinical/kinematics assessments were repeated after therapy, and motor gain was defined as positive values of clinical upper limb/elbow motion changes and negative values of trunk motion changes. Candidate predictors were N -acetylaspartate-neuronal marker, glutamate-glutamine-indicator of glutamatergic neurotransmission, and myo-inositol-glial marker, measured bilaterally within the upper limb territory in motor and premotor (premotor cortex, supplementary motor area) cortices. Traditional predictors (age, stroke length, pre-therapy upper limb clinical impairment, infarct volume) were also investigated. Results: Poor motor gain was associated with lower glutamate-glutamine levels in ipsilesional primary motor cortex and premotor cortex ( r = 0.77, P = 0.01 and r = 0.78, P = 0.008, respectively), lower N -acetylaspartate in ipsilesional premotor cortex ( r = 0.69, P = 0.02), higher glutamate-glutamine in contralesional primary motor cortex ( r = −0.68, P = 0.03), and lower glutamate-glutamine in contralesional supplementary motor area ( r = 0.64, P = 0.04). These predictors outperformed myo-inositol metrics and traditional predictors ( P ≈ 0.05–1.0). Conclusions: Glutamatergic state of bilateral motor and premotor cortices and neuronal state of ipsilesional premotor cortex may be important for predicting motor outcome in the context of a restorative therapy.