Benzethonium chloride activates ER stress and reduces proliferation in HNSCC. (January 2018)

• Record Type: Journal Article
• Authors: Rayess, Hani M.; Xi, Yue; Garshott, Danielle M.; Brownell, Amy L.; Yoo, George H.; Callaghan, Michael U.; Fribley, Andrew M.
• Is Part Of: Oral oncology. Volume 76(2018)
• Page Start: 27
• Page End: 33
• Publication Date: 2018-01
• Subjects: HNSCC -- Head and neck cancer -- High throughput screen -- HTS -- CHOP -- Benzethonium chloride -- Moxidectin -- Unfolded protein response -- ER stress -- OSCC -- Oral cancer; Mouth -- Cancer -- Periodicals; Mouth -- Tumors -- Periodicals; Mouth Diseases -- Periodicals; Mouth Neoplasms -- Periodicals; Bouche -- Cancer -- Périodiques; Bouche -- Tumeurs -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9943105
• DOI: 10.1016/j.oraloncology.2017.11.018
• Languages: English
• ISSNs: 1368-8375

Abstract

Highlights: A HNSCC cell-based HTS was developed to identify molecules that activate UPR. 5 hits activated the CHOP luciferase reporter in a dose dependent manner. Benzethonium chloride (BCl), required intact CHOP to exert an anti-proliferative effect. BCl treatment led to significant increases in CHOP, XBP1 and ATF3 gene expression. BCl treatment resulted in increased CHOP, ATF4 and GRP78/BiP protein transcripts. ABSRACT.