Activatable Singlet Oxygen Generation from Lipid Hydroperoxide Nanoparticles for Cancer Therapy. Issue 23 (4th May 2017)

• Record Type: Journal Article
• Authors: Zhou, Zijian; Song, Jibin; Tian, Rui; Yang, Zhen; Yu, Guocan; Lin, Lisen; Zhang, Guofeng; Fan, Wenpei; Zhang, Fuwu; Niu, Gang; Nie, Liming; Chen, Xiaoyuan
• Is Part Of: Angewandte Chemie international edition. Volume 56:Issue 23(2017)
• Page Start: 6492
• Page End: 6496
• Publication Date: 2017-05-04
• Subjects: apoptosis -- cancer therapy -- iron oxide nanoparticle -- lipid hydroperoxide -- singlet oxygen; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201701181
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Reactive oxygen species (ROS)‐induced apoptosis is a widely practiced strategy for cancer therapy. Although photodynamic therapy (PDT) takes advantage of the spatial–temporal control of ROS generation, the meticulous participation of light, photosensitizer, and oxygen greatly hinders the broad application of PDT as a first‐line cancer treatment option. An activatable system has been developed that enables tumor‐specific singlet oxygen ( 1 O2 ) generation for cancer therapy, based on a Fenton‐like reaction between linoleic acid hydroperoxide (LAHP) tethered on iron oxide nanoparticles (IO NPs) and the released iron(II) ions from IO NPs under acidic‐pH condition. The IO‐LAHP NPs are able to induce efficient apoptotic cancer cell death both in vitro and in vivo through tumor‐specific 1 O2 generation and subsequent ROS mediated mechanism. This study demonstrates the effectiveness of modulating biochemical reactions as a ROS source to exert cancer death. Abstract : Singlet oxygen generation through an activatable biochemical reaction between lipid hydroperoxide and catalytic iron(II) ions from iron oxide nanoparticles was engineered as a novel cancer therapy strategy, which showed promise to exert apoptotic cancer cell death both in vitro and in vivo.