Concise Review: In Vitro Formation of Bone‐Like Nodules Sheds Light on the Application of Stem Cells for Bone Regeneration. (25th July 2016)

• Record Type: Journal Article
• Authors: Mechiche Alami, Saad; Gangloff, Sophie C.; Laurent-Maquin, Dominique; Wang, Yun; Kerdjoudj, Halima
• Is Part Of: Stem cells translational medicine. Volume 5:Number 11(2016)
• Page Start: 1587
• Page End: 1593
• Publication Date: 2016-07-25
• Subjects: Bone-like nodule -- Osteoblast -- Differentiation -- Stem cells -- Extracellular matrix mineralization; Stem cells -- Periodicals; Regenerative medicine -- Periodicals; Periodicals; 616.0277405
• DOI: 10.5966/sctm.2015-0413
• Languages: English
• ISSNs: 2157-6564

Abstract

Abstract : This review summarize the studies deciphering the mechanisms that govern osteoblast differentiation in the context of in vitro formation of bone ‐ like nodules, including morphologic and molecular events as well as cellular contributions to mineral nucleation, occurring during osteogenic differentiation of stem cells. Also highlighted are the limitations of current translational applications of stem cells and opportunities to use the bone ‐ like nodule model for bone regenerative therapies. Abstract : Acknowledgements: Harnessing the differentiation of stem cells into bone‐forming cells represents an intriguing avenue for the creation of functional skeletal tissues. Therefore, a profound understanding of bone development and morphogenesis sheds light on the regenerative application of stem cells in orthopedics and dentistry. In this concise review, we summarize the studies deciphering the mechanisms that govern osteoblast differentiation in the context of in vitro formation of bone ‐ like nodules, including morphologic and molecular events as well as cellular contributions to mineral nucleation, occurring during osteogenic differentiation of stem cells. This article also highlights the limitations of current translational applications of stem cells and opportunities to use the bone ‐ like nodule model for bone regenerative therapies. Harnessing the differentiation of stem cells into bone‐forming cells represents an intriguing avenue for the creation of functional skeletal tissues. Therefore, a profound understanding of bone development and morphogenesis sheds light on the regenerative application of stem cells in orthopedics and dentistry. In this concise review, studies deciphering the mechanisms that govern osteoblast commitment and differentiation are summarized. This article highlights the limitations of current translational applications of stem cells and the opportunities to use the bone‐like nodule model for bone regenerative therapies.