Design and Synthesis of Some New Quinoxaline‐Based Heterocycles. (24th October 2017)

• Record Type: Journal Article
• Authors: El Azab, Islam H.; Elkanzi, Nadia A. A.; Gobouri, Adil A.
• Is Part Of: Journal of heterocyclic chemistry. Volume 55:Number 1(2018)
• Page Start: 65
• Page End: 76
• Publication Date: 2017-10-24
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.2978
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : Considering quinoxaline as a privileged structure for developing probes of impressive therapeutic potentials, some new azole and azine conjugates of quinoxaline were synthesized. Thus, ethyl 3‐amino‐1, 4‐dihydroquinoxaline‐2‐carboxylate (2 ) was prepared as one‐pot three‐component product and incorporated in a series of manipulations including cyclocondensation reactions to afford a series of pharmacophoric motif conjugates8–12, 14, 15–17, 20–23, 24–29, 30 –37, and38–43 in fair yields. The newly synthesized were characterized by IR, 1 H NMR, 13 C NMR, and mass spectral data. Abstract :