A New Class of Boronic Acid‐Derived Amphiphile‐Based Gel Emulsions Capable of Entrapping and Releasing Vitamin B12 and Doxorubicin. Issue 23 (16th August 2017)

• Record Type: Journal Article
• Authors: Roy, Sumita; Maiti, Monali; Roy, Aparna
• Is Part Of: ChemistrySelect. Volume 2:Issue 23(2017)
• Page Start: 6929
• Page End: 6939
• Publication Date: 2017-08-16
• Subjects: Boronic acid amphiphile -- entrapment and release -- Gel-emulsion -- Morphology -- Rheology; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201701397
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: In this work, two boronic acid based amphiphiles, Sodium salt of 2‐amidodecylpyridine‐5‐boronic acid (SADPB) and Sodium salt of 2‐amidododecylpyridine‐5‐boronic acid (SADDPB) have been synthesized and their gel‐emulsion property in organic solvents were investigated. The good gelation ability of the amphiphiles was confirmed by low minimum gelation concentration ( MGC ) and high gelation number ( Ngel ) values. Theoretical study established that introduction of amide linkage in the amphiphilic structure dismantles aggregate formation. The gel‐emulsions are stable towards mechanical and thermal responses. The gelation process is also dependent on the nature of solvent and type of amphiphiles. The morphology of gel‐emulsions is highly dependent on the concentration of the amphiphile. The prepared gel‐emulsions are able to encapsulate and release biomolecule vitamin B12 and anticancer drug doxorubicin at room temperature. Both vitamin B12 and doxorubicin exhibited retention of their structures and activity which has been recognized this new type of boronic acid based amphiphiles as efficient drug delivery vehicles. Abstract : A detailed investigation of the gel‐emulsion property of two amidoalkyl boronic acid derivatives has been carried out. The mechanically and thermally stable gel‐emulsions showed concentration dependent morphological changes. Spectroscopic studies established the entrapping and releasing ability of vitamin B12 and doxorubicin hydrochloride at room temperature with retention of structure and activity.