Sporadic Desmoid Tumors of the Abdominal Wall: The Results of Surgery. Issue 6 (November 2016)

• Record Type: Journal Article
• Authors: Mussi, Chiara E.; Colombo, Piergiuseppe; Russo, Chiara Lo; Kasangian, Anaid; Cananzi, Ferdinando; Marrari, Andrea; Morenghi, Emanuela; De Sanctis, Rita; Quagliuolo, Vittorio
• Is Part Of: Tumori. Volume 102:Issue 6(2016)
• Page Start: 582
• Page End: 587
• Publication Date: 2016-11
• Subjects: Aggressive fibromatosis -- Beta-catenin mutation -- Desmoid tumor -- Pregnancy -- S45F mutation -- Tumor of abdominal wall; Cancer -- Periodicals; 616.994
• DOI: 10.5301/tj.5000552
• Languages: English
• ISSNs: 0300-8916

Abstract

Purpose: Before the wait-and-see policy became the standard approach in abdominal wall desmoid tumors, surgery was performed on a systematic basis. Surgery remains indicated for progressing tumors but its extent is debatable. The abdominal wall is a common site of origin of sporadic desmoids, usually associated with a favorable prognosis. We analyzed the results of surgery at this specific site. Methods: Data from 33 patients affected by sporadic desmoid tumors of the abdominal wall (31 primary, 2 recurrent) consecutively treated at our cancer center between January 2000 and September 2013 were retrospectively studied. Results: Twenty-nine patients underwent surgery upfront and 1 after progression during the initial wait-and-see period. Prosthetic reconstruction of the abdominal wall was required in 28 patients. The average hospital stay was 5 days. Three patients developed surgical complications. Local recurrence-free survival was 90% at 5 and 10 years. Three patients had an uneventful childbirth during the follow-up after surgery. Conclusions: Desmoid tumors of the abdominal wall have a favorable prognosis after surgical resection, which remains a safe and effective treatment. Wild-type tumors are common, whereas the incidence of S45F mutation in the beta-catenin gene is lower than in other anatomic sites. Upfront surgery may be considered in selected women who wish to bear a child.