N‐acylsulfonamides: Synthetic routes and biological potential in medicinal chemistry. (11th July 2017)

• Record Type: Journal Article
• Authors: Ammazzalorso, Alessandra; De Filippis, Barbara; Giampietro, Letizia; Amoroso, Rosa
• Is Part Of: Chemical biology & drug design. Volume 90:Number 6(2017)
• Page Start: 1094
• Page End: 1105
• Publication Date: 2017-07-11
• Subjects: acylsulfonamides -- antiproliferative -- bioisosteres -- PPAR -- sulfonamides; Drugs -- Design -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; 615.19005
• DOI: 10.1111/cbdd.13043
• Languages: English
• ISSNs: 1747-0277

Abstract

Abstract : Sulfonamide is a common structural motif in naturally occurring and synthetic medicinal compounds. The rising interest in sulfonamides and N ‐acyl derivatives is attested by the large number of drugs and lead compounds identified in last years, explored in different fields of medicinal chemistry and showing biological activity. Many acylsulfonamide derivatives were designed and synthesized as isosteres of carboxylic acids, being the characteristics of these functional groups very close. Starting from chemical routes to N ‐acylsulfonamides, this review explores compounds of pharmaceutical interest, developed as enzymatic inhibitors or targeting receptors. Abstract : Many acylsulfonamide derivatives were designed and synthesized as isosteres of carboxylic acids, being the characteristics of these functional groups very close. Starting from chemical routes to N ‐acylsulfonamides, this review explores compounds of pharmaceutical interest, developed as enzymatic inhibitors or targeting receptors.