NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients. (October 2018)

• Record Type: Journal Article
• Authors: Malhotra, Sunny; Sorosina, Melissa; Río, Jordi; Peroni, Silvia; Midaglia, Luciana; Villar, Luisa M; Álvarez-Cermeño, José C; Schroeder, Ina; Esposito, Federica; Clarelli, Ferdinando; Zettl, Uwe K; Lechner-Scott, Jeannette; Spataro, Nino; Navarro, Arcadi; Comi, Giancarlo; Montalban, Xavier; Martinelli-Boneschi, Filippo; Comabella, Manuel
• Is Part Of: Multiple sclerosis. Volume 24:Number 11(2018)
• Page Start: 1507
• Page End: 1510
• Publication Date: 2018-10
• Subjects: Multiple sclerosis -- inflammasome -- polymorphisms -- interferon-beta; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458517739137
• Languages: English
• ISSNs: 1352-4585

Abstract

We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNβ and NLRP3 polymorphisms. These findings do not support a role of polymorphisms located in the NLRP3 gene and the response to IFNβ in MS patients.