Role of IL-8, CRP and epidermal growth factor in depression and anxiety patients treated with mindfulness-based therapy or cognitive behavioral therapy in primary health care. (August 2017)

• Record Type: Journal Article
• Authors: Memon, Ashfaque A.; Sundquist, Kristina; Ahmad, Abrar; Wang, Xiao; Hedelius, Anna; Sundquist, Jan
• Is Part Of: Psychiatry research. Volume 254(2017)
• Page Start: 311
• Page End: 316
• Publication Date: 2017-08
• Subjects: Biomarkers -- Cytokines -- Inflammation -- Psychotherapy; Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2017.05.012
• Languages: English
• ISSNs: 0165-1781

Abstract

Abstract: Epidermal growth factor (EGF) and inflammatory markers have been associated with various neuro-psychiatric disorders. However, their role in mild to moderate depression and anxiety patients treated with mindfulness-based group therapy (mindfulness) or cognitive behavioral therapy (CBT) is not known. In this study we analyzed plasma levels of interleukin (IL)-6, IL-8, high sensitivity C-reactive protein (hsCRP) and EGF before (baseline) and after treatment (8 weeks) and investigated their role in response to both arms of the treatment. To cover variety of mental symptoms, treatment response was analyzed by four scales, the Montgomery–Åsberg depression rating scale (MADRS), Hospital anxiety and depression scale- Depression (HADS-D) and anxiety (HADS-A) and patients health questionnaire-9. EGF levels were significantly decreased after both mindfulness and CBT and were associated with treatment response on all scales independent of the use of tranquilizers and antidepressant treatment. Moreover, baseline EGF levels were significantly associated only with baseline scores of anxiety scale. Levels of inflammatory markers analyzed in this study, were not significantly associated with treatment response on any scale. Our findings suggest that improvement in symptoms of depression and anxiety after both mindfulness and CBT is associated with changes in EGF levels but not with the inflammatory markers. Highlights: Mindfulness-based therapy and CBT were equally effective in patients with mild to moderate depression and anxiety. However, molecular mechanism underlying the improvement in symptoms is unknown. Here, we show that changes in epidermal growth factor levels are associated with response to both mindfulness-based therapy as well as CBT. In contrast, levels of inflammatory markers were not significantly affected by either of these therapies. Our results indicate that both therapies may have similar molecular mechanism associated with the response.