Chemical and Biological Aspects of Nutritional Immunity—Perspectives for New Anti‐Infectives that Target Iron Uptake Systems. Issue 46 (13th October 2017)

• Record Type: Journal Article
• Authors: Bilitewski, Ursula; Blodgett, Joshua A. V.; Duhme‐Klair, Anne‐Kathrin; Dallavalle, Sabrina; Laschat, Sabine; Routledge, Anne; Schobert, Rainer
• Is Part Of: Angewandte Chemie international edition. Volume 56:Issue 46(2017)
• Page Start: 14360
• Page End: 14382
• Publication Date: 2017-10-13
• Subjects: antibiotics -- heme proteins -- iron -- nutritional immunity -- siderophores; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201701586
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Upon bacterial infection, one of the defense mechanisms of the host is the withdrawal of essential metal ions, in particular iron, which leads to "nutritional immunity". However, bacteria have evolved strategies to overcome iron starvation, for example, by stealing iron from the host or other bacteria through specific iron chelators with high binding affinity. Fortunately, these complex interactions between the host and pathogen that lead to metal homeostasis provide several opportunities for interception and, thus, allow the development of novel antibacterial compounds. This Review focuses on iron, discusses recent highlights, and gives some future perspectives which are relevant in the fight against antibiotic resistance. Abstract : Fighting fit : The fight for essential metal ions is like a tug of war between pathogens and host cells. Interference in this struggle can lead to new ways to fight antibiotic resistance.