Prospective memory is dysfunctional in migraine without aura. (October 2018)

• Record Type: Journal Article
• Authors: Santangelo, Gabriella; Russo, Antonio; Tessitore, Alessandro; Garramone, Federica; Silvestro, Marcello; Della Mura, Maria Rosaria; Marcuccio, Laura; Fornaro, Ilaria; Trojano, Luigi; Tedeschi, Gioacchino
• Is Part Of: Cephalalgia. Volume 38:Number 12(2018)
• Page Start: 1825
• Page End: 1832
• Publication Date: 2018-10
• Subjects: Migraine -- prospective memory -- cognitive deficit -- cognitive dysfunction -- depression -- apathy; Headache -- Periodicals; 616.8491
• DOI: 10.1177/0333102418758280
• Languages: English
• ISSNs: 0333-1024

Abstract

Introduction: Prospective memory is the ability to carry out a delayed intended action, so to maintain and retrieve future plans, goals and activities. Deficits of prospective memory negatively impact on patients and caregivers' everyday living and determine poor adherence to treatment. Since frontal regions are involved in both event- and time-based prospective memory tasks and are impaired in migraine without aura, defects of prospective memory might occur in migraine without aura patients; until now this issue has not been investigated. The aim of the current study was to explore time- versus event-based prospective memory in migraine without aura. Patients and methods: Ninty-one consecutive migraine without aura patients and 84 healthy subjects were enrolled in the study. They underwent a standardized measure of prospective memory evaluating both time-based and event-based prospective memory, and the Montreal Cognitive Assessment assessing global cognitive status. Moreover, all participants completed the Beck Depression Inventory-II and a self-administered version of the Apathy Evaluation Scale, to assess severity of depressive symptoms and apathy, respectively. Results: Migraine without aura and healthy subjects did not differ on demographic aspects (i.e. age, education and gender). However, individuals with migraine without aura demonstrated impaired prospective memory performance compared to healthy subjects, with a greater impairment demonstrated for the time-based tasks. Within the migraine without aura group, no significant association was found between prospective memory performance and clinical scores, apathy, and depression. Conclusions: Individuals with migraine without aura experience particular difficulty executing a future intention; therefore, migraine without aura is associated with dysfunction of prospective memory.