Choroidal Neovascularization in Multifocal Choroiditis after Dabrafenib and Trametinib. Issue 6 (8th November 2017)

• Record Type: Journal Article
• Authors: Albertini, Giorgia C.; Corbelli, Eleonora; Battaglia Parodi, Maurizio; Bandello, Francesco
• Is Part Of: European journal of ophthalmology. Volume 27:Issue 6(2017)
• Page Start: e184
• Page End: e186
• Publication Date: 2017-11-08
• Subjects: Choroidal neovascularization -- Dabrafenib and trametinib -- Metastatic melanoma -- Multifocal choroiditis; Ophthalmology -- Periodicals; Eye -- Diseases -- Periodicals; 617.7005
• DOI: 10.5301/ejo.5001013
• Languages: English
• ISSNs: 1120-6721

Abstract

Purpose: To describe a case of bilateral choroidal neovascularization (CNV) in multifocal choroiditis (MFC) associated with dabrafenib and trametinib chemotherapy for metastatic melanoma. Case: We present a case of a 57-year-old man with MFC who underwent combination therapy with dabrafenib plus trametinib for metastatic melanoma. The patient presented to our ophthalmology department complaining of bilateral vision loss of 2 days' duration. He underwent multimodal imaging showing a MFC reactivation complicated by bilateral CNV. The patient underwent 3 ranibizumab injections in the right eye and 7 ranibizumab injections in the left eye. Anatomical and functional improvement has been observed. Conclusions: This report emphasizes the importance of strict ophthalmologic follow-up in patients with metastatic melanoma treated with dabrafenib plus trametinib since rare severe ocular toxicities can occur, especially in patients with a history of uveitis.