Posterior Polymorphous Corneal Dystrophy Concomitant to Large Colloid Drusen. Issue 2 (March 2015)

• Record Type: Journal Article
• Authors: Del Turco, Claudia; Pierro, Luisa; Querques, Giuseppe; Gagliardi, Marco; Corvi, Federico; Manitto, Maria Pia; Bandello, Francesco M.
• Is Part Of: European journal of ophthalmology. Volume 25:Issue 2(2015)
• Page Start: 177
• Page End: 179
• Publication Date: 2015-03
• Subjects: Large colloid drusen -- Posterior polymorphous corneal dystrophy -- Optical coherence tomography -- Macular dystrophy -- Young -- Early-onset; Ophthalmology -- Periodicals; Eye -- Diseases -- Periodicals; 617.7005
• DOI: 10.5301/ejo.5000526
• Languages: English
• ISSNs: 1120-6721

Abstract

Purpose: To describe the previously unreported concomitance of 2 uncommon ocular conditions: posterior polymorphous corneal dystrophy (PPCD) and large colloid drusen (LCD). Methods: A 45-year-old woman underwent a complete ophthalmologic examination with slit-lamp biomicroscopy and blue fundus autofluorescence with spectral-domain optical coherence tomography, as well as complete systemic examination and renal function investigation. Results: On slit-lamp biomicroscopy, a corneal lesion located at Descemet membrane was observed in the right eye. The clinical features of deep posterior stromal-endothelial linear bands with vesicles and irregular opacities of posterior corneal surface were consistent with the diagnosis of PPCD. Fundus biomicroscopy and blue fundus autofluorescence showed LCD. Discussions: We report the unusual coexistence of PPCD and LCD in a young, healthy subject. Posterior polymorphous corneal dystrophy and LCD share morphologic similarities and dysfunctions of collagen architecture in the basement membrane layer, which suggests a possible common pathogenic pathway.