Using soil properties to predict in vivo bioavailability of lead in soils. (November 2015)

• Record Type: Journal Article
• Authors: Wijayawardena, M.A. Ayanka; Naidu, Ravi; Megharaj, Mallavarapu; Lamb, Dane; Thavamani, Palanisami; Kuchel, Tim
• Is Part Of: Chemosphere. Volume 138(2015)
• Page Start: 422
• Page End: 428
• Publication Date: 2015-11
• Subjects: Sorption -- Relative bioavailability -- Swine -- In vivo -- Soil properties; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2015.06.073
• Languages: English
• ISSNs: 0045-6535

Abstract

Highlights: RB of Pb in swine dosed with Pb spiked soils ranged from 30 ± 9% to 83 ± 7%. Kd of Pb in soils ranged from 21 to 234 L/kg showing widely different binding. A strongly significant ( R 2 = 0.94) exponential relationship exists between RB and Kd . This model can help predict potentially bioavailable Pb in contaminated soils. Abstract: Soil plays a significant role in controlling the potential bioavailability of contaminants in the environment. In this study, eleven soils were used to investigate the relationship between soil properties and relative bioavailability (RB) of lead (Pb). To minimise the effect of source of Pb on in vivo bioavailability, uncontaminated study soils were spiked with 1500 mg Pb/kg soil and aged for 10–12 months prior to investigating the relationships between soil properties and in vivo RB of Pb using swine model. The biological responses to oral administration of Pb in aqueous phase or as spiked soils were compared by applying a two-compartment pharmacokinetic model to blood Pb concentration. The study revealed that RB of Pb from aged soils ranged from 30 ± 9% to 83 ± 7%. The very different RB of Pb in these soils was attributed to variations in the soils' physico-chemical properties. This was established using sorption studies showing: firstly, Freundlich partition coefficients that ranged from 21 to 234; and secondly, a strongly significant ( R 2 = 0.94, P < 0.001) exponential relationship between RB and Freundlich partition coefficient ( Kd ). This simple exponential model can be used to predict relative bioavailability of Pb in contaminated soils. To the best of our knowledge, this is the first such model derived using sorption partition coefficient to predict the relative bioavailability of Pb.