Characteristic Profiles of Inflammatory Cytokines in the Aqueous Humor of Glaucomatous Eyes. (17th November 2018)

• Record Type: Journal Article
• Authors: Kokubun, Taiki; Tsuda, Satoru; Kunikata, Hiroshi; Yasuda, Masayuki; Himori, Noriko; Kunimatsu-Sanuki, Shiho; Maruyama, Kazuichi; Nakazawa, Toru
• Is Part Of: Ocular immunology and inflammation. Volume 26:Number 8(2018)
• Page Start: 1177
• Page End: 1188
• Publication Date: 2018-11-17
• Subjects: Aqueous humor -- cytokine -- glaucoma -- NVG -- POAG; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2017.1327605
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : To analyze cytokine profiles of the aqueous humor of eyes with primary open-angle glaucoma (POAG), neovascular glaucoma (NVG), and cataract (as controls). Methods : A multiplex bead assay was used to measure concentrations of 27 cytokines in aqueous humor samples from 54 eyes. Results : Detection rates were as follows: IL-7: NVG higher than POAG; IL-10: POAG lower than cataract or NVG; and GM-CSF: cataract higher than POAG or NVG. Concentrations were as follows: IL-8, IP-10, MCP-1, and MIP-1β: POAG and NVG higher than cataract; IL-9: POAG lower than NVG; IL-12: POAG lower than cataract or NVG; and VEGF: NVG higher than cataract or POAG and POAG lower than cataract. Further analysis showed that IL-8, IP-10, MCP-1, and MIP-1β were correlated with intraocular pressure and age. Conclusions : The detection rates and levels of various cytokines had different patterns in POAG and NVG patients, suggesting distinctive alterations in the microenvironment in different types of glaucoma.