Energy metabolism disorders in rare and common diseases. Toward bioenergetic modulation therapy and the training of a new generation of European scientists. (June 2015)

• Record Type: Journal Article
• Authors: Rossignol, Rodrigue
• Is Part Of: International journal of biochemistry & cell biology. Volume 63(2015:Jun.)
• Page Start: 2
• Page End: 9
• Publication Date: 2015-06
• Subjects: Bioenergetics -- Regulation -- Drug development -- Metabolic therapy; ACS acute coronary syndrome -- ALS amyotrophic lateral sclerosis -- AMPK amp-activated protein kinase -- ATP adenosine triphosphate -- BIOMET bioenergetic modulation therapy -- CI complex I -- CKD chronic kidney disease -- EMD energy metabolism disorders -- ETC electron transport chain -- FH fumarate hydratase -- GDF15 growth differentiation factor 15 -- HIF1α hypoxia-inducible factor1 alpha -- HSP hereditary spastic paraplegias -- IDH isocitrate dehydrogenase -- MEET Mitochondrial European Educational Training -- MiDis mitochondrial diseases -- MOA mechanism of action -- mtDNA mitochondrial DNA -- NAMPT nicotinamide phosphoribosyltransferase -- nDNA nuclear DNA -- NRF2 nuclear respiratory factor 2 -- OPA1 optic atrophy 1 -- OXPHOS oxidative phosphorylation -- PEPCK phosphoenolpyruvate carboxykinase -- PGC1α Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha -- PKM2 pyruvate kinase M2 isoform -- ROS reactive oxygen species -- SDH succinate dehydrogenase -- TFAM mitochondrial transcription factor A; Biochemistry -- Periodicals; Cytology -- Periodicals; Biochemistry -- Periodicals; Cell Biology -- Periodicals; Biochimie -- Périodiques; Cytologie -- Périodiques; Biochimie; Cytologie; Biochemistry; Cytology; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); Periodicals; 572.05
• DOI: 10.1016/j.biocel.2015.01.003
• Languages: English
• ISSNs: 1357-2725

Abstract

Abstract: Energy metabolism alterations are found in a large number of rare and common diseases of genetic or environmental origin. The number of patients that could benefit from bioenergetic modulation therapy (BIOMET) is therefore very important and includes individuals with pathologies as diverse as mitochondrial diseases, acute coronary syndrome, chronic kidney disease, asthma or even cancer. Although, the alteration of energy metabolism is disease specific and sometimes patient specific, the strategies for BIOMET could be common and target a series of bioenergetic regulatory mechanisms discussed in this article. An excellent training of scientists in the field of energy metabolism, related human diseases and drug discovery is also crucial to form a young generation of MDs, PHDs and Pharma or CRO-group leaders who will discover novel personalized bioenergetic medicines, through pharmacology, genetics, nutrition or adapted exercise training. The Mitochondrial European Educational Training (MEET) consortium was created to pursue this goal, and we dedicated here a special issue of Organelle in Focus (OiF) to highlight their objectives. A total of 10 OiFs articles constitute this Directed Issue on Mitochondrial Medicine. As part of this editorial article, we asked timely questions to the PR. Jan W. Smeitink, professor of Mitochondrial Medicine and CEO of Khondrion, a mitochondrial medicine company. He shared with us his objectives and strategies for the study of mitochondrial diseases and the identification of future treatments. This article is part of a Directed Issue entitled: Energy Metabolism Disorders and Therapies.