Synthesis and antiprotozoal activity of mono- and bis-uracil isatin conjugates against the human pathogen Trichomonas vaginalis. Issue 16 (15th August 2015)

• Record Type: Journal Article
• Authors: Kumar, Kewal; Liu, Nicole; Yang, Donald; Na, Daniel; Thompson, John; Wrischnik, Lisa A.; Land, Kirkwood M.; Kumar, Vipan
• Is Part Of: Bioorganic & medicinal chemistry. Volume 23:Issue 16(2015)
• Page Start: 5190
• Page End: 5197
• Publication Date: 2015-08-15
• Subjects: Uracil-isatin conjugates -- Trichomonas vaginalis -- Cytotoxicity -- Structure activity relationship; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; Chemistry, Clinical -- Periodicals; Chemistry, Organic -- Periodicals; Chimie bio-organique -- Périodiques; Chimie pharmaceutique -- Périodiques; 615.19
• DOI: 10.1016/j.bmc.2015.04.075
• Languages: English
• ISSNs: 0968-0896

Abstract

Graphical abstract: Synthesis and anti-trichomonas activity of uracil-isatin conjugates. Abstract: A library of mono- and bis-uracil isatin conjugates were synthesized and subjected for the assessment of their in vitro activity against the protozoal pathogen Trichomonas vaginalis . The structure activity studies (SAR) revealed that the bis-uracil-isatin based conjugates were more effective than their corresponding mono conjugates in inhibiting the growth of T. vaginalis at approximately 10 μM with no visual effect on mammalian cells at the same concentration.