Coati Bodies: Cytoplasmic Hyaline Globules in the Ganglionic Neurons of Aging Captive Coatis. (September 2017)

• Record Type: Journal Article
• Authors: Cooper, Timothy K.; Garner, Michael M.; Baccon, Jennifer; Mani, Haresh
• Is Part Of: Veterinary pathology. Volume 54:Number 5(2017:Sep.)
• Page Start: 851
• Page End: 854
• Publication Date: 2017-09
• Subjects: inclusion bodies -- paradrenal ganglia -- Meissner's plexus -- Auerbach's plexus -- coati -- Nasua narica -- Nasua nasua -- coatimundi -- procyonids -- ultrastructure; Veterinary pathology -- Periodicals; Pathology, Veterinary -- Periodicals; 636.089607
• DOI: 10.1177/0300985817709886
• Languages: English
• ISSNs: 0300-9858

Abstract

Intensely eosinophilic and glassy intracytoplasmic inclusions were present in the neurons of the peripheral autonomic ganglia, Meissner's and Auerbach's plexus, and spinal ganglia in 20 aged white-nosed coatis ( Nasua narica, 7–19 years old) and in 4 of 7 brown-nosed coatis ( Nasua nasua, 2–21 years old) from multiple zoological institutions. Inclusions were single to numerous, sometimes distorting the cell. Pheochromocytomas were present in 5 of 16 white-nosed and 2 of 6 brown-nosed coatis, although no inclusions were present in the adrenal glands. Histochemically, immunohistochemically, and ultrastructurally, these inclusions were consistent with dense neurosecretory granules. Although similar inclusions have been reported sporadically in the adrenal medulla of humans and several other mammalian species as both incidental and pathologic findings, ganglionic inclusions reported herein appear to be unique and related to age in these species.