Atypical cytologic presentation of a histiocytic sarcoma in a Cavalier King Charles Spaniel dog. (July 2017)

• Record Type: Journal Article
• Authors: Clarke, Lorelei L.; Kelly, Lisa S.; Garner, Bridget; Brown, Cathy A.
• Is Part Of: Journal of veterinary diagnostic investigation. Volume 29:Number 4(2017:Jul.)
• Page Start: 541
• Page End: 543
• Publication Date: 2017-07
• Subjects: Adrenal gland -- canine -- cytology -- histiocytic sarcoma; Veterinary medicine -- Diagnosis -- Periodicals; 636.0896075
• DOI: 10.1177/1040638717701521
• Languages: English
• ISSNs: 1040-6387

Abstract

A Cavalier King Charles Spaniel dog was presented because of a 10-d history of progressive vomiting, inappetence, and lethargy, with mild neurologic signs. Fine-needle aspirates of splenic nodules seen on ultrasound were suggestive of a carcinoma. On autopsy, a disseminated neoplasm was present in the lung, spleen, and adrenal glands. Additionally, there was a Chiari-like malformation of the skull with corresponding syringomyelia of the cranial spinal cord. Histologically, the neoplasm was comprised of a pleomorphic population of round cells with a high mitotic rate. Cells stained positive for vimentin and CD18 and negative for cytokeratin, chromogranin A, CD3, CD20, MHC II, and CD11d, and hence the tumor was diagnosed as a histiocytic sarcoma. The cytologic presentation in this case is uncommon for this type of tumor, as was the clinical presentation.