Myocardial perfusion and left ventricular function indices assessed by gated myocardial perfusion SPECT in methamphetamine abusers. Issue 12 (December 2016)

• Record Type: Journal Article
• Authors: Dadpour, Bita; Dabbagh Kakhki, Vahid R.; Afshari, Reza; Dorri-giv, Masoumeh; Mohajeri, Seyed A.R.; Ghahremani, Somayeh
• Is Part Of: Nuclear medicine communications. Volume 37:Issue 12(2016:Dec.)
• Publication Date: 2016-12
• Subjects: amphetamine -- cardiomyopathy -- coronary artery disease -- gated SPECT -- methamphetamine -- myocardial perfusion SPECT; Nuclear medicine -- Periodicals; 616.07575
• DOI: 10.1097/MNM.0000000000000585
• Languages: English
• ISSNs: 0143-3636

Abstract

Abstract : Objectives: Methamphetamine (MA) is associated with alterations of cardiac structure and function, although it is less known. In this study, we assessed possible abnormality in myocardial perfusion and left ventricular function using gated myocardial perfusion SPECT. Methods: Fifteen patients with MA abuse, on the basis of Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV) MA dependency determined by Structured Clinical Interview for DSM-IV, underwent 2-day dipyridamole stress/rest 99m Tc-sestamibi gated myocardial perfusion SPECT. Results: An average daily dose of MA use was 0.91±1.1 (0.2–4) g. The duration of MA use was 3.4±2.1 (1–7) years. In visual and semiquantitative analyses, all patients had normal gated myocardial perfusion SPECT, with no perfusion defects. In all gated SPECT images, there was no abnormality in left ventricular wall motion and thickening. All summed stress scores and summed rest scores were below 3. Calculated left ventricular functional indices including the end-diastolic volume, end-systolic volume, and left ventricular ejection fraction were normal. Conclusion: Many cardiac findings because of MA mentioned in previous reports are less likely because of significant epicardial coronary artery stenosis.