Transgelin-2: A potential oncogenic factor. Issue 6 (June 2017)

• Record Type: Journal Article
• Authors: Meng, Ti; Liu, Leichao; Hao, Ruifang; Chen, Siying; Dong, Yalin
• Is Part Of: Tumor biology. Volume 39:Issue 6(2017)
• Publication Date: 2017-06
• Subjects: Transgelin-2 -- TAGLN2 -- biological function -- cancer development -- actin-binding proteins; Cancer -- Periodicals; Oncology -- Periodicals; Tumors -- Periodicals; 616.994
• DOI: 10.1177/1010428317702650
• Languages: English
• ISSNs: 1010-4283

Abstract

Actin-binding proteins are proteins that could bind to actin or actin fibers. As a member of actin-binding proteins, Transgelin-2 is expressed in smooth muscle cells and non-smooth muscle cells, and its gene, TAGLN2, is differently expressed in all cells and tissues. The deregulation of Transgelin-2 is considered to be correlated with progression of many kinds of diseases, especially the development of malignant tumors, such as invasion, metastasis, and resistance, yet the function and mechanism of action of Transgelin-2 remain elusive. Therefore, we reviewed the basic characteristics and function of Transgelin-2 and its biological role in various types of diseases in order to provide the theoretical basis for further research and new perspectives on cancer development.