The esophageal mucosa and submucosa: immunohistology in GERD and Barrett's esophagus. (11th October 2013)

• Record Type: Journal Article
• Authors: Appelman, Henry D.; Streutker, Catherine; Vieth, Michael; Neumann, Helmut; Neurath, Markus F.; Upton, Melissa P.; Sagaert, Xavier; Wang, Helen H.; El‐Zimaity, Hala; Abraham, Susan C.; Bellizzi, Andrew M.
• Is Part Of: Annals of the New York Academy of Sciences. Volume 1300(2013)
• Page Start: 144
• Page End: 165
• Publication Date: 2013-10-11
• Subjects: eosinophilic esophagitis -- muscularis mucosae -- multilayered epithelium -- lamina propria -- dilated intercellular spaces -- markers -- transcription factors; Medical sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; 610
• DOI: 10.1111/nyas.12241
• Languages: English
• ISSNs: 0077-8923

Abstract

Abstract : This paper presents commentaries on the microscopic morphology of esophageal squamous epithelium; the frequency of duplication of the muscularis mucosae (MM) in Barrett's esophagus (BE); the significance of multilayered epithelium; whether cells in the lamina propria reflect those in the epithelium; how stem cells are identified in the squamous esophagus; dilated intercellular spaces; the metastasizing potential of early carcinoma‐dependent, molecular or immunohistochemical tests that improve diagnosis; the role of immunohistochemistry IHC in grading of neoplasia in Barrett's esophagus and defining the risk of progression to adenocarcinoma; the roles of CDX1 and CDX2 in squamous and cardiac mucosa; and the role of desmosomal cadherins and lectins in squamous and cardiac mucosa.