Nanoscale Metal–Organic Layers for Deeply Penetrating X‐ray‐Induced Photodynamic Therapy. (25th August 2017)

• Record Type: Journal Article
• Authors: Lan, Guangxu; Ni, Kaiyuan; Xu, Ruoyu; Lu, Kuangda; Lin, Zekai; Chan, Christina; Lin, Wenbin
• Is Part Of: Angewandte Chemie. Volume 129:Number 40(2017)
• Page Start: 12270
• Page End: 12274
• Publication Date: 2017-08-25
• Subjects: Krebs -- Metall-organische Schichten -- Nanomaterialien -- Photodynamische Therapie -- Röntgenstrahlung; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201704828
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: We report the rational design of metal–organic layers (MOLs) that are built from [Hf6 O4 (OH)4 (HCO2 )6 ] secondary building units (SBUs) and Ir[bpy(ppy)2 ] + ‐ or [Ru(bpy)3 ] 2+ ‐derived tricarboxylate ligands (Hf‐BPY‐Ir or Hf‐BPY‐Ru; bpy=2, 2′‐bipyridine, ppy=2‐phenylpyridine) and their applications in X‐ray‐induced photodynamic therapy (X‐PDT) of colon cancer. Heavy Hf atoms in the SBUs efficiently absorb X‐rays and transfer energy to Ir[bpy(ppy)2 ] + or [Ru(bpy)3 ] 2+ moieties to induce PDT by generating reactive oxygen species (ROS). The ability of X‐rays to penetrate deeply into tissue and efficient ROS diffusion through ultrathin 2D MOLs (ca. 1.2 nm) enable highly effective X‐PDT to afford superb anticancer efficacy.