Terahertz Thermometry: Combining Hyperspectral Imaging and Temperature Mapping at Terahertz Frequencies. Issue 5 (15th August 2017)

• Record Type: Journal Article
• Authors: Naccache, Rafik; Mazhorova, Anna; Clerici, Matteo; Piccoli, Riccardo; Khorashad, Larousse Khosravi; Govorov, Alexander O.; Razzari, Luca; Vetrone, Fiorenzo; Morandotti, Roberto
• Is Part Of: Laser & photonics reviews. Volume 11:Issue 5(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-08-15
• Subjects: photothermal generation -- plasmonic nanorods -- teramometry -- thermal mapping -- hyperspectral imaging; Lasers -- Periodicals; Photonics -- Periodicals; Lasers -- Périodiques; Photonique -- Périodiques; 621.36
• DOI: 10.1002/lpor.201600342
• Languages: English
• ISSNs: 1863-8880

Abstract

Abstract : A terahertz‐based thermal‐mapping/hyperspectral imaging method is demonstrated in a biological model system. Hyperspectral imaging of a drug formulation is realized subcutaneously, in the presence of plasmonically heated gold nanorods. Abstract: The accurate and non‐invasive determination of multiple physical parameters, with well‐defined spatial resolution, is crucial for applications in manufacturing, chemistry, medicine and biology. Specifically, the ability to simultaneously measure both temperature and spectral signatures is still experimentally unavailable. To this end, we propose a mapping technique for biological systems, which exploits a linear correlation between terahertz wave reflectivity and temperature, and allows to spatially and spectrally resolve thermal distributions. This method is applied to a model biological system in two relevant cases where in one example, nanoplasmonic‐induced photothermal effects are imaged gaining new insights into collective heating phenomena. In the second example, we demonstrate a joint thermal‐hyperspectral imaging approach to chemically map the presence of a model drug formulation and simultaneously investigate its thermal stability in our biological system. This concept can be easily extended and widely applied to all materials that demonstrate a measurable change in their dielectric properties.