Blockable Zn10L15 Ion Channels through Subcomponent Self‐Assembly. (3rd November 2017)

• Record Type: Journal Article
• Authors: Haynes, Cally J. E.; Zhu, Jinbo; Chimerel, Catalin; Hernández‐Ainsa, Silvia; Riddell, Imogen A.; Ronson, Tanya K.; Keyser, Ulrich F.; Nitschke, Jonathan R.
• Is Part Of: Angewandte Chemie. Volume 129:Number 48(2017)
• Page Start: 15590
• Page End: 15594
• Publication Date: 2017-11-03
• Subjects: Lipidmembranen -- Metall-organische Käfige -- Selbstorganisation -- Supramolekulare Chemie -- Synthetische Ionenkanäle; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201709544
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Metal–organic anion channels based on Zn10 L15 pentagonal prisms have been prepared by subcomponent self‐assembly. The insertion of these prisms into lipid membranes was investigated by ion‐current and fluorescence measurements. The channels were found to mediate the transport of Cl − anions through planar lipid bilayers and into vesicles. Tosylate anions were observed to bind and plug the central channels of the prisms in the solid state and in solution. In membranes, dodecyl sulfate blocked chloride transport through the central channel. Our Zn10 L15 prism thus inserts into lipid bilayers to turn on anion transport, which can then be turned off through addition of the blocker dodecyl sulfate.