Results from the post-exposure prophylaxis pilot program (P-QUAD) demonstration project in Los Angeles County. (May 2018)

• Record Type: Journal Article
• Authors: Beymer, Matthew R; Kofron, Ryan M; Tseng, Chi-Hong; Bolan, Robert K; Flynn, Risa P; Sayles, Jennifer M; Perez, Mario J; Jordan, Wilbert C; Landovitz, Raphael J
• Is Part Of: International journal of STD & AIDS. Volume 29:Number 6(2018)
• Page Start: 557
• Page End: 562
• Publication Date: 2018-05
• Subjects: Antiretroviral therapy -- high-risk behavior -- HIV -- homosexual -- North America; Sexually transmitted diseases -- Periodicals; AIDS (Disease) -- Periodicals; 616.951
• DOI: 10.1177/0956462417743158
• Languages: English
• ISSNs: 0956-4624

Abstract

Post-exposure prophylaxis (PEP) is a promising but under-utilized strategy for HIV prevention in high-risk populations. Between March 2010 and June 2011, two community-based clinics in Los Angeles County provided PEP in a pilot program to 267 unique individuals. Courses were primarily dispensed to men who have sex with men (84%) and consisted overwhelmingly of a three-drug antiretroviral therapy regimen containing two nucleoside reverse transcriptase inhibitors and either an integrase inhibitor (raltegravir) or a boosted protease inhibitor (lopinavir/ritonavir). Approximately 64% of all PEP courses were followed for at least 12 weeks, and seven individuals seroconverted. Of the seven seroconversions, six had subsequent re-exposure. The low rate of PEP failure calls for expanded funding for PEP in other jurisdictions.